Dr. Loh Keh Chuan

Dr. Loh Keh Chuan has been practising as Consultant Endocrinologist in Mount Elizabeth Medical Centre since 2004. Prior to starting his private practice, he had previously served in the public sector as a Senior Consultant in Tan Tock Seng Hospital and a Visiting Consultant to both Thyroid Clinic at National Cancer Centre and Endocrine Clinic at KK Women’s and Children’s Hospital. He had published over 50 clinical and research papers in peer-reviewed medical journals and authored several book chapters on various endocrine topics. Besides diabetes and general endocrinology, his special interest is in thyroid diseases, including ultrasound-guided biopsy and sclerotherapy of thyroid nodules, and thyroid cancer management. Dr. Loh was a former expert panel member for Clinical Practice Guideline for Thyroid Cancer Management in the Asia Pacific Region as well as Ministry of Health Clinical Practice Guideline for Diabetes Mellitus.

A INTERNATIONAL JOURNALS
1. Chng HH, Leong KP, Loh KC. Primary systemic allergy to human insulin: Recurrence of generalized urticaria
after successful desensitization. Allergy (Copenhagen) 1995; 50:984-987.
2. Loh KC, Shlossberg AH, Rittmaster R, Holness RO. Giant prolactinomas: A retrospective review. The
Endocrinologist (Williams & Wilkins, USA) 1996; 6:257-263.
3. Loh KC, Gupta R, Shlossberg AH. Spontaneous remission of ectopic Cushing’s syndrome due to
pheochromocytoma: A case report. European Journal of Endocrinology 1996; 135:440-443.
4. Loh KC, Tan MH. Reverse cholesterol transport: Its contribution to cholesterol catabolism in normal and
disease states. Canadian Journal of Cardiology 1996; 12:944-950.
5. Loh KC, Shlossberg AH, Abbott EC, Salisbury SR, Tan MH. Phaeochromocytoma: A ten-year survey. Quarterly
Journal of Medicine (Oxford) 1997; 90:51-60.
6. Loh KC. Familial nonmedullary thyroid carcinoma: A meta-review of case series. Thyroid (USA) 1997; 7:107-
113.
7. Loh KC, Salisbury SR, Acott PD, Crocker JF. Central precocious puberty in a boy with chronic renal failure:
Reversibility post renal transplantation. Journal of Pediatric Endocrinology & Metabolism 1997; 10:539-545.

8. Loh KC, Greenspan FS, Gee L, Miller TR, Yeo PPB. pTNM classification for papillary and follicular thyroid
carcinomas: A retrospective analysis of 700 patients. Journal of Clinical Endocrinology and Metabolism 1997;
82:3553-3562.
9. Loh KC, Green A, Dillon WP Jr, Fitzgerald PA, Weidner N, Tyrrell JB. Diabetes insipidus from sarcoidosis
confined to the posterior pituitary. European Journal of Endocrinology 1997; 137:514-519.
10. Loh KC, Fitzgerald PA, Matthay KK, Yeo PPB, Price D. Treatment of malignant pheochromocytomas with
iodine-131-metaiodobenzylguanidine: a comprehensive review of 116 reported patients. Journal of Endocrinological
Investigation (Italy) 1997; 20:648-658.
11. Tan MH, Loh KC, Dobiasova M, Frohlich JJ. Fractional esterification rate of HDL particles in NIDDM patients.
Diabetes Care 1998; 21:139-142.
12. Loh KC, Duh QY, Shoback D, Gee L, Siperstein A, Clark OH. Clinical profile of primary hyperparathyroidism in
adolescents and young adults. Clinical Endocrinology (Oxford) 1998; 48:435-443.
13. Loh KC, Fitzgerald PA, Miller TR, Tyrrell JB. Perils and pitfalls in the diagnosis of Cushing’s syndrome: Lessons
from a case report. Western Journal of Medicine 1998; 169:46-50.
14. Lo JC, Loh KC, Rubin AL, Cha I, Greenspan FS. Riedel’s thyroiditis presenting with hypothyroidism and
hypoparathyroidism: Dramatic response to glucocorticoid and thyroxine therapy. Clinical Endocrinology (Oxford)
1998; 48:815-818.
15. Loh KC, Tan MH. Alpha-glucosidase inhibitor and treatment of diabetes mellitus: a drug review. Endocrine
Practice (USA)1998; 4:287-293.
16. Loh KC, Matthay KK, Hoover M, Bracho FA, Cortez AB, Conte FA, Albanese CT, Miller TR, Price DC, Flores AJ,
Kaviani A, Shoback D. Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein
(PTHrP). Hormone Research 1998; 50:217-221.
17. Loh KC, Greenspan FS, Dong F, Miller TR, Yeo PPB. Influence of Lymphocytic Thyroiditis on the Prognostic
Outcome of Patients with Papillary Thyroid Carcinoma. Journal of Clinical Endocrinology & Metabolism 1999; 84:458-
463.
18. Loh KC, Chee YC. Pregnancy and The Thyroid: A Clinical Review. Proceedings of the Royal College of
Physicians of Edinburgh 1999; 29:204-210.
19. Loh KC. Amiodarone and the Thyroid: A Clinical Review. Postgraduate Medical Journal, 2000; 76:133-140.
20. Loh KC, Koay ES, Khaw MC, Emmanuel SC, Young WF Jr. Prevalence of primary aldosteronism among Asian
hypertensive patients in Singapore. Journal of Clinical Endocrinology & Metabolism 2000; 85:2854-2859.
21. Wu HS, Young MT, Ituarte PHG, D’Avanzo A, Duh Q-Y, Greenspan FS, Loh KC, Clark OH. Death from Thyroid
Cancer of Follicular Cell Origin. Journal of American College of Surgeons 2000; 191:600-606.
22. Tan YLJ, Loh KC, Yeo GSH, Chee YC. Transient hyperthyroidism of hyperemesis gravidarum. Br J Obstets &
Gynaecol 2002; 109:683-8.
23. Tan NCK, Tan AKY, Sitoh YY, Loh KC, Leow KS, Tjia HTL. Paroxysmal exercise-induced dystonia associated with
hypoglycaemia induced by an insulinoma (Letter). J Neurol 2002; 249:1615-1616.
24. Leow MKS, Loh KC. Fatal thyroid crisis years after two thyroidectomies for Graves’ disease: Is thyroid tissue
autotransplantation for post-thyroidectomy hypothyroidism worthwhile? (Letters to the Editor) J Am Coll Surg 2002;
195:434-5.

25. Gil Y, Loh KC. Scleroderma-like skin changes in patients with diabetes (review). J Am Acad Dermatol 2003;
48:109-11.
26. P Mulatero, M Stowasser, K-C Loh, CE Fardella, R Gordon, L Mosso, CE Gomez-Sanchez, F Veglio and WF
Young Jr. Extensive Personal Experience: Increased Diagnosis of Primary Aldosteronism, Including Surgically
Correctable Forms, in Centers from Five Continents. Journal of Clinical Endocrinology & Metabolism 2004; 85: 2854-
9.
27. F Sundram, BG Robinson, A Kung, MA Lim-Abrahan, QB Nguyen, KC Loh, JH Chung, S-M Huang, L-C Hsu, N
Kamaruddin, WK Cheah, WB Kim, S-S Koong, HD Lin, A Mangklabruks, E Paz-Pacheco, A Rauff, PW Ladenson. Well-
Differentiated Epithelial Thyroid Cancer Management in the Asia Pacific Region: A Report and Clinical Practice
Guideline. Thyroid 2006; 16:461-9.
28. MKS Leow, KC Loh, KK Tong, PY Ng. Catecholamine and Metanephrine Excess in Intracranial Haemorrhage:
Revisiting an obscure yet common “Pseudo-phaeochromocytoma” (Letters to the Editor) J Clin Pathol 2007; 60:583-
4.
29. Leow MKS, Loh KC, Zhu M, Chan SP, Sundram FX. Iodine-131 Therapy for Hyperthyroidism Prescribed by
Endocrinologist – Our Preliminary Experience. Exp Clin Endocrinol Diabetes (Published online 2008)
B. LOCAL JOURNALS
1. Loh KC, Chan KW, Sng I. Primary Pulmonary Lymphoma: Report of three cases and a brief review of the
literature. Annals, Academy of Medicine, Singapore 1994; 23:400-405.
2. Loh KC, Chan KW, Sittampaplam K, Chia FKE, Chin KW. Case of pulmonary alveolar proteinosis treated by
sequential whole-lung lavages and a review of the condition. Annals, Academy of Medicine, Singapore 1995; 24:447-
452.
3. Loh KC, Eng PCT. Prevalence and prognostic relevance of sick euthyroid syndrome in a medical intensive care
unit. Annals, Academy of Medicine, Singapore 1995; 24:802-806.
4. Loh KC, Leong KH, Low YP, Low CH, Yap WM. Primary hyperparathyroidism: A case with severe skeletal
manifestations. Annals, Academy of Medicine, Singapore 1995; 24:874-878.
5. Loh KC, Leo YS, Heng MK, Goh BC. Murine typhus: A forgotten cause of febrile illness in Singapore. Singapore
Medical Journal 1996; 37:39-43.
6. Loh KC, Thai AC, Lui KF, Ng WY. High prevalence of dyslipidaemia despite adequate glycaemic control in
patients with diabetes. Annals, Academy of Medicine, Singapore 1996; 25:228-232.
7. Loh KC, Yap WM, Chia FKE. Ectopic Cushing's syndrome in a young female with atypical bronchial carcinoid
tumour. Singapore Medical Journal 1997; 38:29-31.
8. Loh KC, Shlossberg AH. Large macroprolactinoma treated with bromocriptine alone. Annals, Academy of
Medicine, Singapore 1996; 25:866-869.
9. Loh KC, Lo JC, Greenspan FS, Miller TR, Yeo PPB. Familial papillary thyroid cancer: A case report. Annals,
Academy of Medicine, Singapore 1997; 26:503-506.
10. Ho HK, Loh KC. Hyperthyroidism with gynaecomastia as the initial complaint: A case report. Annals, Academy
of Medicine, Singapore 1998; 27:594-596.
11. Loh KC, Lo JC, Zaloudek C, Fitzgerald PA. Occult virilizing ovarian neoplasms in postmenopausal women:
Evaluation difficulties with reference to a case. Annals, Academy of Medicine, Singapore 1998; 27:712-6.

12. Loh KC. Cyclical Cushing’s Syndrome: A Trap for the Unwary. Singapore Medical Journal 1999; 40:321-324.
13. Loh KC. Overview of Endocrine Hypertension (Invited Article). Singapore Family Physician 1998; 24:7-12.
14. Loh KC. Diagnosis and management of thyrotoxic Graves’ disease (Invited Article). Singapore Family
Physician 1999; 25:3-9.
15. Loh KC. Approach to a Patient with suspected Primary Aldosteronism. Singapore Medical Journal 1999;
40:371-374.
16. Kon YC, Loh KC, Chew SP, Yap WM, Lee YS, Low CH. Hypoglycaemia from islet cell hyperplasia and
nesidioblastosis in a patient with type 2 diabetes mellitus – A case report. Annals, Academy of Medicine, Singapore
2000; 29:682-687.
17. Leow KS, Loh KC. 46 XY Female – A Case Report. Annals, Academy of Medicine, Singapore 2001; 30:71-75.
(corresponding author)
18. Goh SY, Loh KC. Gynaecomastia caused by traditional Chinese Herbal compound “Dong Quai”. Singapore
Medical Journal 2001; 42:115-116. (corresponding author)
19. Loh KC. [Reply from Authors] Singapore Medical Journal 2001; 42:287.
20. Kon YC, Loh KC, Tambyah JA, Lim LH, Marshall JC. TSH-secreting pituitary macroadenoma with cavernous
sinus invasion. Singapore Medical Journal 2001; 42:433-437. (corresponding author)
21. Loh KC, Leow KS. Current Therapeutic Strategies in Patients with Type 2 Diabetes Mellitus (Invited CPD
Article). Annals, Academy of Medicine, Singapore 2002; 31:722-730.
22. Loh KC. Management of Nodular Thyroid Diseases: A Review (Invited Article). Singapore Family Physician
2003; 29:54-57.
23. Leow KS, Loh KC, Kon YC, Wong ES, Tan BS, Soon PC. Clinical Utility of Selective Intra-arterial Calcium-
Stimulated Hepatic Venous Sampling in Regionalisation of Insulinomas – The Singapore Experience. (corresponding
author). Annals, Academy of Medicine, Singapore 2003; 32:86-91.
24. Loh KC, Leow KS. Update on Hyperlipidaemia: Screening and Classification
(Invited Article). Singapore Family Physician 2003; 29:19-21.
25. Loh KC. Pharmacology of Oral Anti-hyperglycaemic Agents & Insulin (Invited Article).
Singapore Family Physician 2004; 30:16-20.
26. Loh KC, Pinheiro L, Ng KS. Thyrotoxic periodic paralysis complicated by near-fatal ventricular arrhythmias.
Singapore Med J 2005; 46:88-89.
27. Leow MK, Loh KC. Accidental provocation of phaeochromocytoma: the forgotten hazard of metoclopramide?
Singapore Med J 2005; 46: 557-560.
28. Leow MK, Loh KC. Controversial endocrine interventions for the aged. (Review Article) Singapore Med J
2006; 47: 569-579.
29. Loh KC. Insulin and their uses (Invited Article). Singapore Family Physician 2007; 33:22-25.
C. CONTRIBUTION TO BOOK CHAPTERS
1. Yeo PPB, Loh KC. Subclinical thyrotoxicosis. In: Advances in Internal Medicine, Mosby Year-book for 1998;

Vol 43:501-532.
2. Loh KC. Endocrine Emergencies. In: Bedside ICU Handbook 2000. Tai YH, Lew WK (Eds), Tan Tock Seng
Hospital, Singapore.
3. Loh KC, Greenspan FS, Miller TD. Differentiated Thyroid Carcinomas. In: Endocrine Tumors, Clark et al (Ed),
American Cancer Society, BC Decker, Canada, 2003.

1. Ministry of Health HMDP Fellowship Award in Endocrinology, Dalhousie University, Halifax, Canada (1995-6)
2. TTSH HMDP Fellowship Award in Endocrinology, University of California
San Francisco, CA, USA (1996-7)
3. The U.S. Endocrine Society Travel Grant Award for Meritorious Abstract (1997)

1. Life Member, Endocrine & Metabolic Society of Singapore
2. Life Member, Singapore Medical Association
3. Member, American Association of Clinical Endocrinologists
4. Member, US Endocrine Society
5. Member, American Thyroid Association