Dr. Stephen Chang

Dr Stephen Chang is a general surgeon and subspecializes in laparoscopic surgery, management of gall bladder, liver
and pancreatic diseases.
Dr Stephen Chang graduated with MBBS at the National University of Singapore (NUS) in 1994 and obtained his
Master of Medicine (Surgery) in 2000 from NUS. Having become a fellow of the Royal College of Surgeons of
Edinburgh, UK in 2003, he furthered his training in laparoscopic hepatobiliary and pancreatic surgery, and liver
transplantation in Paris, France.
Dr Chang pioneered the single incision laparoscopic surgery (SILS) in Singapore and was the first few to publish his
experience in single incision laparoscopic gallbladder surgery, liver resection and pancreas resection.
He is an Adjunct Associate Professor in NUS and has more than 100 publications in both clinical and Medtech
research and has since filed >5 patents in these areas. With these endeavours, he hopes to improve the care of
patients.
Dr Chang is the founding president of the Hepatopancreatobiliary Association of Singapore. During his 4-year tour as
president, he spear-headed the Liver Disease Awareness Week where he raised funds to provide free hepatitis B
screening for Singaporeans.
Dr Stephen Chang is also active in medical missions in Cambodia, Thailand, Iran, Indonesia and Timor Leste. He is a
co-founder of a Medical Aids by SG Knights which helped to ease the mask shortage and COVID situation during the
earlier days of the pandemic.

Minimally invasive surgical treatment of abdominal and digestive organs including liver, pancreas and gallbladder

Single port laparoscopic appendicectomy
Single port laparoscopic cholecystectomy
Single port laparoscopic liver resection
Single port laparoscopic distal pancreatectomy

Academic Awards
1. 2004 Health Manpower Development Programme Award (Hepatopancreaticobiliary and Laparoscopic
Surgery)
Hospital Henri Mondor, Creteil, Paris – Prof Daniel Cherqui
Hospital Beaujon, Clichy, Paris – Prof Jacques Belghiti
Hospital Paul Brousse, Villejuif Paris – Prof Rene Adam
Institut Mutualiste Montsouris, Paris – Prof Brice Gayet
Imperial College London, Hammersmith – Prof Nagy Habib
2. 2010 Health Manpower Development Programme Award (Team-Based) –
(Multi-organ Transplant)
Toronto General Hospital, Canada
RESEARCH
Scientific Award
1. Best Innovation in Biomedical and Pharmaceutical Applications (NI ASEAN GSD Achievement Awards 2011)
2. Best publication Award Annals Academy of Medicine 2017 (Bronze)
Grants Awarded (Total Sum – S$7,123,467.23)
1. Cord-stem cell Application for Regeneration Enhancement (CARE) (May 2011-Nov 2013) ($200,000.00)
 NMRC Exploratory / Development Grant (EDG). Principal Investigator
2. Cryopreserved cadaveric vascular grafts: Studying the long term effects of Cryopreservation (2007 – 2012)
(S$166,000.00).
 NMRC New Investigator Grant. Principal Investigator.
3. Development of an Ablation and Division Device with blood- flow sensor feature (10/7/2008-31/7/2010)
(S$150,000.00).
 NMRC Exploratory/ Development Grant. Principal Investigator.
4. Liver progenitor cells in chronic liver injury – a potential source of autologous cells for liver tissue engineering
(S$124,000.00).
 NMRC New Investigator Grant. Co-Investigator.
5. Simulation-based design, development and experiment of augmented reality surgery (S $177,000.00).
 Faculty Research Committee Start-up Grant. Collaborator
6. Characterization of anisotropic healthy, pathological and ablated liver tissue using quantitative MR
elastography (S$68,000.00).
 JSPS-NUS Joint Research Project. Co- Investigator.
7. Image-guided Robot Assisted Surgical training (2008 – 2011) (S$ 575,790.00)
 SERC. Principal Medical Investigator

8. Phase III Multi-Centre Open-Label Randomized Controlled Trial Of Selective Internal Radiation Therapy
(SIRT) Versus Sorafenib In Locally Advanced Hepatocellular Carcinoma (SIRveNIB) (AHCC06) (4/10/2010 –
28/4/2015) ($48,000.00)
 Principal Investigator
9. Clinician Investigator Salary Support Programme (CISSP) (Dec 2010-April 2015) (S$530,999.23)
10. Biocompatible Real-time Implantable Close-loop Glucose-control System (BRICGS) (1/1/2011 – 31/12/2012)
(S$450,000.00)
 SCEI. Principal Medical Investigator
11. Image Guided Robotic Assisted Surgical Training (IRAS) (Jan 2011-June 2013) (S$1,341,190.00)
 SCEI. Clinical Principal Investigator
12. Robotic-Assisted Training for Basic Laparoscopic Skills – A novel teaching tool (Sept 2012 – Mar 2014)
(S$9,000.00)
 NUHS Innovation and Creativity in Education (NICE) Fund. Principal Project Manager
13. Image and model-based human-robot collaborative system for large liver tumor ablation – (1 April 2013 – 31
March 2016) (S$ 298,500)
 SINGAPORE – CHINA 9 TH JOINT RESEARCH PROGRAMME (SG-CN JRP) GRANT CALL 2012.
Medical Principal Investigator

14. Pre-clinical validation for first in manby the Ablation and Division Device with blood flow sensor (ADD) – (14
August 2014 – 13 August 2015) (S$ 245,938)
 NRF POC 2014. Principal Investigator

15. Transcutaneous Robot-assisted Ablation-device Insertion Navigation System (TRAINS) – (15 October 2014 –
15 April 2016) ($439,050)
 BEP 2013 Grant Call. Lead Clinical Co-Principal Investigator
16. Clinical Validation (First-in-man) of the Ablation and Division Device with blood flow sensor
(ADD) – (1 Mar 2015 -28 Feb 2017) ($150,000.00)
 NUHS Clinician Research Grant FY14
17. The Eradication of Chronic Hepatitis B – (Dec 2014 – Dec 2019) ($1mil)
 TCR Grant. Co-PI
18. Integrated Identification and Characterisation of Hepatocellular Carcinoma Subtypes for
Enhanced Personalised Medical Diagnosis and Treatment – (16 Feb 2015 – 15 Feb 2017) ($1mil)
 Yong Siew Yoon Research Grant. Co-I
19. Epigenetic Approach to Treating MYC-driven Hepatic Tumors – (1 Mar 2015 -28 Feb 2017)
($150,000.00)
 Seed Fund for Basic Science Research Grant
20. Clinician Investigator Salary Support Programme (CISSP) (May 2015-April 2016) (S$75,000)

CURRENT APPOINTMENT
Medical Director, GLAD Clinic,
Founding President, Hepatopancreatobiliary Association of Singapore
Founding Member, International Laparoscopic Liver Society
Singapore Representative, Asia Pacific Laparoscopic Hepatectomy Promotion and Development Expert Committee
Adjunct Associate Professor, National University of Singapore

PREVIOUS APPOINTMENT
Council-at-large, Asia Pacific Hepatopancreatobiliary Association
Medical Director, Liver Transplant Program, Mt Elizabeth Hospital, Singapore
Head (Acting). Senior Consultant and Research Director
Division of Hepatobiliary and Pancreatic Surgery & Liver Transplant
Lead, Liver Tumor Group
National University Cancer Institute, Singapore
National University Health System
Clinical Director
Medical Engineering Research & Commercialisation Initiative (MERCI)
Department of Surgery, National University of Singapore
Director
Medical Student Observership & Job Shadowing Programme
University Surgical Cluster
National University Hospital, Singapore
Associate Professor, Department of Surgery
YLL School of Medicine National University of Singapore